Organic Letters
Organic Letters
5 years ago

Organocatalytic Para-Selective Amination of Phenols with Iminoquinone Monoacetals

Organocatalytic Para-Selective Amination of Phenols with Iminoquinone Monoacetals
Qing-Long Xu, Xiaoan Wen, Liu Liu, Hongbin Sun, Peng-Fei Wang, Hang-Yu Song, Wen-Zhen Wu, Kun Chen
A highly selective para C–H amination of unprotected phenols with iminoquinone acetals was realized, giving the functional phenols in good to excellent yields. Overall, this transformation is operationally simple, proceeds with readily available phenols, and has wide substrate scope and low catalyst loading. The biarylamine product is stochastically formed via [5,5]-sigmatropic rearrangement of a mixed acetal species which is generated in situ under the reaction conditions.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01700

DOI: 10.1021/acs.orglett.7b01700

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.