Monomeric and fibrillar {alpha}-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of A{beta}42 aggregates [Biophysics and Computational Biology]
![Monomeric and fibrillar {alpha}-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of A{beta}42 aggregates [Biophysics and Computational Biology]](/image/eyJ1cmkiOiJodHRwOi8vc3RhY2thZGVtaWMuaGVyb2t1YXBwLmNvbS9pbWFnZT9pbWFnZV9pZD0yMDY4IiwiZm9ybWF0Ijoid2VicCIsInF1YWxpdHkiOjEwMCwibm9DYWNoZSI6dHJ1ZX0=.webp)
The coaggregation of the amyloid-β peptide (Aβ) and α-synuclein is commonly observed in a range of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. The complex interplay between Aβ and α-synuclein has led to seemingly contradictory results on whether α-synuclein promotes or inhibits Aβ aggregation. Here, we show how these conflicts can be rationalized and resolved by demonstrating that different structural forms of α-synuclein exert different effects on Aβ aggregation. Our results demonstrate that whereas monomeric α-synuclein blocks the autocatalytic proliferation of Aβ42 (the 42-residue form of Aβ) fibrils, fibrillar α-synuclein catalyses the heterogeneous nucleation of Aβ42 aggregates. It is thus the specific balance between the concentrations of monomeric and fibrillar α-synuclein that determines the outcome of the Aβ42 aggregation reaction.
Publisher URL: http://feedproxy.google.com/~r/Pnas-RssFeedOfEarlyEditionArticles/~3/Gp-JCIbJlug/1700239114.short
DOI: 10.1073/pnas.1700239114
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