3 years ago

Towards the use of bioresorbable fibers in time-domain diffuse optics

Towards the use of bioresorbable fibers in time-domain diffuse optics
Antonio Pifferi, Diego Pugliese, Nadia G. Boetti, Alberto Dalla Mora, Edoardo Ceci-Ginistrelli, Andrea Farina, Davide Janner, Sanathana Konugolu Venkata Sekar, Daniel Milanese, Laura Di Sieno
In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 μm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for time-domain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500–1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 μm core bioresorbable fiber. In this work, we add a step toward a new way to look inside the body using bioresorbable optical fibers that can be implanted in patients. We described their fabrication and we demonstrate their suitability in retrieving optical properties (related to tissue components and structure). Bioresorbable fibers respond to the need of low cost and minimally invasive instruments for diagnostics (e. g. follow-up after surgical interventions) or treatments (e. g. photodynamic therapy).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jbio.201600275

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