Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Inside Back Cover: Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex (Chem. Eur. J. 39/2017)

Inside Back Cover: Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex (Chem. Eur. J. 39/2017)
Niels Johan Christensen, Jesper Wengel, Peter W. Thulstrup, Kasper K. Sørensen, Søren Roi Midtgaard, Manuel C. Martos-Maldonado, Knud J. Jensen, Chenguang Lou, Maria Ejlersen
Peptide-oligonucleotide conjugates (POC) were used for the self-assembly of miniature coiled-coil α-helical peptides guided by oligonucleotide duplex and triplex formation. The POC consisted of three oligonucleotides each with a 23-mer peptide attached. The oligonucleotide domains gave a parallel triplex that templated the peptides to form a small coiled-coil motif with high degree of α-helicity. Cooperativity was observed between the trimeric peptide and the oligonucleotide triplex domains. More information can be found in the Full Paper by J. Wengel et al. on page 9297.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701745

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