4 years ago

Room-Temperature CuI-Catalyzed Amination of Aryl Iodides and Aryl Bromides

Room-Temperature CuI-Catalyzed Amination of Aryl Iodides and Aryl Bromides
Dongchen Du, Xiaomei Ding, Xinhai Zhu, Yiqian Wan, Zhou Yi, Manna Huang
A general and effective CuI/N′,N′-diaryl-1H-pyrrole-2-carbohydrazide catalyst system was developed for the amination of aryl iodides and bromides at room temperature with good chemoselectivity between −OH and −NH2 groups. Only 5 mol % of CuI and ligands was needed in this protocol to effect the amination of various aryl bromides and aryl iodides with a wide range of aliphatic and aryl amines (1.3 equiv).

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00290

DOI: 10.1021/acs.joc.7b00290

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