Current Topics in Developmental Biology
Current Topics in Developmental Biology
5 years ago

Chapter Two The Function and Evolution of Nuclear Receptors in Insect Embryonic Development

Nuclear receptors are a family of transcription factors that are often responsive to small ligands, allowing for efficient gene expression-level responses to a stimulus. The average insect has 21 genes encoding nuclear receptors, whose functions are especially well studied in developmental transitions during the insect life cycle, such as metamorphosis and molting. However, their utility as well-controlled transcriptional regulators also lends them to important roles in embryogenesis, neurogenesis, metabolism, and organogenesis. Such developmental functions have been explored in depth in the model organism Drosophila melanogaster. More recently, advances in genomic resources and functional genomic methodologies have allowed for comparison of nuclear receptor function among a wider range of insect species. As has been the trend throughout the field of Evo-Devo, these new data sets reveal that many genes are shared, but the ways in which they are utilized in different lineages are more variable. In this chapter, we describe the suite of nuclear receptor genes found in Drosophila and their developmental functions. We then compare and contrast these genes and their functions in diverse insects.

Publisher URL: www.sciencedirect.com/science

DOI: S0070215317300030

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.