5 years ago

Type 1 diabetes, cognition and the neurologist: Exploring Go/No-Go and Maze tasks in the search for a practical screening tool

The objectives were to use inexpensive and easy-to-apply tasks in order to investigate the differences between type 1 diabetes mellitus (T1DM) patients and controls regarding attention and impulsivity, which are the basis for key-executive function components that are traditionally assessed using subjective, long and difficult to reproduce questionnaires. Additionally, we sought to correlate these differences with clinical characteristics, and to explore correlations between the tasks. Methods We compared the scores of 20 T1DM patients with 20 controls. The sample population included both males and females, aged 12–15 years. They were tested using a Go/No-Go paradigm and a Maze task, and correlations were verified between the groups. Results The T1DM group had more anticipatory answers (AA) in the Go/No-Go task (p <0.05), and made more direction changes in Mazes (p<0.01). There was a correlation between non-severe hypoglycemia and AA (p=0.01), as well as between severe hypoglycemia and the number of touches in Mazes’ walls (p<0.05). Glycated hemoglobin (HbA1c)>9% correlated with a greater number of alleys in Mazes (p<0.05). The tasks’ parameters were coherent among each test, and also between them. Conclusions We found indicators of inattention and impulsivity to be associated with T1DM, with inattention being closely related with hyperglycemia, and impulsivity being associated with hypoglycemia. Further research is needed to study diabetes-associated cognitive decline with more objective parameters, and to analyse the reliability and psychometric properties of the tasks proposed in this study.

Publisher URL: www.sciencedirect.com/science

DOI: S0736574816303458

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.