5 years ago

The effects of nifedipine on respiratory mechanics investigated by theend-inflation occlusion method in the rat

The effects of nifedipine on respiratory mechanics investigated by theend-inflation occlusion method in the rat
Daniele del Monte, Vincenzo Catena, Alessandro Rubini, Gerardo Bosco


Context: Calcium channel blockers may theoretically exhibit relaxing effects not only on vascular smooth muscle but also on airway smooth muscle.

Objective: To investigate possible effects of nifedipine on respiratory mechanics in the rat.

Methods: Respiratory system mechanical parameters were measured by the end-inflation occlusion method in the rat in vivo before and after the intraperitoneal administration of nifedipine.

Results: We found that nifedipine affects respiratory mechanics, inducing a reduction of airway resistance and of respiratory system elastance, probably because of a relaxing action on airway and parenchimal smooth muscle cells.

Conclusion: Should these results be further confirmed by human investigations, a possible role of nifedipine in pharmacological respiratory system’s diseases treatment may be suggested.

Publisher URL: http://tandfonline.com/doi/full/10.1080/14756366.2016.1225045

DOI: 10.1080/14756366.2016.1225045

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