ChemMedChem
ChemMedChem
5 years ago

DNA microcapsule for photo-triggered drug release system

Takahiro Muro, Hiroyuki Asanuma, Yoshinobu Yamada, Yukiko Kamiya, Kazunori Matsuura
In this study, we constructed spherical, photo-responsive microcapsules composed of three photo-switchable DNA strands. These strands first formed a three-way junction (TWJ) motif that further self-assembled to form microsphere through hybridization of the sticky-end regions of each branch. To serve as the photo-switch, multiple unmodified azobenzene (Azo) or 2,6-dimethyl-4-(methylthio)azobenzene (SDM-Azo) were introduced into the sticky-end regions via a D-threoninol linker. The DNA-capsule structure deformed upon trans-to-cis isomerization of Azo or SDM-Azo induced by specific light-irradiation. In addition, photo-triggered release of encapsulated small molecules from the DNA-microcapsule was successfully achieved. Moreover, we demonstrated that photo-triggered release of doxorubicin caused cytotoxicity to cultured cells. This biocompatible photo-responsive microcapsule has potential applications as a photo-controlled drug release system.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cmdc.201700512

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