ChemMedChem
ChemMedChem
5 years ago

Front Cover: Simultaneous Multiple MS Binding Assays Addressing D1 and D2 Dopamine Receptors (ChemMedChem 19/2017)

Front Cover: Simultaneous Multiple MS Binding Assays Addressing D1 and D2 Dopamine Receptors (ChemMedChem 19/2017)
Klaus T. Wanner, Georg Höfner, Marion Schuller
The Front Cover shows affinity profiling at two dopamine receptor subtypes in a single binding experiment following the concept of Simultaneous Multiple Mass Spectrometry (MS) Binding Assays. SCH23390 (left) and raclopride (right) were used as nonlabeled reporter ligands addressing the D1 and the D2 subtype, respectively, which could be monitored by LC-MS/MS. In this way, simultaneous affinity determination for dopamine receptor antagonists at both targets was possible. The results obtained demonstrate the high versatility of MS binding assays that appears to surpass what is common for conventional radioligand binding assays. More information can be found in the Full Paper by Klaus T. Wanner et al. on page 1585 in Issue 19, 2017 (DOI: 10.1002/cmdc.201700369).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cmdc.201700580

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