Structure-optimized dihydropyranoindole derivative GIBH-LRA002 potentially reactivated viral latency in primary CD4+ T lymphocytes of chronic HIV-1 patients

5 years ago

Structure-optimized dihydropyranoindole derivative GIBH-LRA002 potentially reactivated viral latency in primary CD4+ T lymphocytes of chronic HIV-1 patients

Caijun Sun, Qing Yang, Yuyang Ding, Junling Zhao, Enxiang Pan, Xiuchang Ma, Ling Chen, Xiaozhen Fan, Fengling Feng

Based on structure modification and a high-throughput Jurkat-Lat cell screening model, we found that GIBH-LRA002 effectively reactivated the latent proviruses but without inducing systemic activation, making this compound attractive for potentially treating HIV-1 infection.

Publisher URL: http://feeds.rsc.org/~r/rss/MD/~3/4Qp6bp45g0s/C7MD00327G

DOI: 2017/MD/C7MD00327G

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