4 years ago

Dual In-Tether Chiral Centers Modulate Peptide Helicity

Dual In-Tether Chiral Centers Modulate Peptide Helicity
Wenjun Li, Chengjie Sun, Yixiang Jiang, Zigang Li, Huacan Lin, Kuan Hu, Jialin Guo, Mengying Yu, Chengxiang Lei
The facile chemical modification on the peptide cross-linking moiety is an important strategy for improving the physicochemical properties of a peptide. Herein, peptides were constrained into helical conformations via the synergistic effects of dual in-tether chiral centers. A pentapeptide minimalistic model was used to determine the correlation between the absolute configurations of the dual in-tether chiral centers and the secondary structures of the peptides. This strategy provides an on-tether modification site that does not interrupt the secondary structure of the peptide.

Publisher URL: http://dx.doi.org/10.1021/acs.bioconjchem.7b00171

DOI: 10.1021/acs.bioconjchem.7b00171

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