Proteomics - Clinical Applications
Proteomics - Clinical Applications
5 years ago

Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics

Nonhlanhla P. Khumalo, Khwezikazi Mkentane, Reginald M. Ngwanya, Jennifer C Wyk, Afolake Arowolo, Henry A. Adeola
The use of non-invasive human substrates to interrogate pathophysiological conditions has become essential in the post- Human Genome Project (HGP) era. Due to its high turnover rate, and its long term capability to incorporate exogenous and endogenous substances from the circulation; hair testing is emerging a key player in monitoring long term drug compliance, chronic alcohol abuse, forensic toxicology, and biomarker discovery, among other things. Novel high throughput ‘omics based approaches like proteomics have been underutilized globally in comprehending human hair morphology and its evolving use as a diagnostic testing substrate in the era of precision medicine. There is paucity of scientific evidence that evaluates the difference in drug incorporation into hair based on lipid content; and very few studies have addressed hair growth rates, hair forms and the biological consequences hair grooming or bleaching. It is apparent that protein-based identification using the human hair proteome would play a major role in understanding these parameters akin to deoxyribonucleic acid (DNA) single nucleotide polymorphism (SNP) profiling, up to single amino acid polymorphism (SAP) resolution. Hence, this work seeks to identify and discuss the progress made thus far in the field of molecular hair testing using proteomic approaches, and identify ways in which proteomics would improve the field of hair research, considering that the human hair is mostly composed of proteins. Gaps in hair proteomics research were identified; and the potential of hair proteomics in establishing a historic medical repository of normal and disease-specific proteome was also discussed. This article is protected by copyright. All rights reserved

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/prca.201700048

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