5 years ago

cis-Platinum Complex Encapsulated in Self-Assembling Cyclic Peptide Dimers

cis-Platinum Complex Encapsulated in Self-Assembling Cyclic Peptide Dimers
Rebeca García-Fandiño, María Isabel Loza, José Brea, Manuel Amorín, Juan R. Granja, Nuria Rodríguez-Vázquez, María J. Aldegunde
A new cyclic peptide dimer that encapsulates cisplatin complexes in its internal cavity is described. The resulting complex showed cytotoxic activity at A2780 ovarian cancer cell lines independent of acquired platinum resistance.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00871

DOI: 10.1021/acs.orglett.7b00871

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