Neuropeptides
Neuropeptides
5 years ago

Involvement of GABAA receptors in the regulation of social preference and emotional behaviors by oxytocin in the central amygdala of female mandarin voles

The central nucleus of the amygdala (CeA) is the main output of the amygdala and plays an important role in behavioral and neuroendocrine responses to stress. Receptors for the neuropeptide oxytocin (OT) and GABAA are found in high concentration in the CeA. The mechanisms underlying regulation of CeA OT in emotional and social behavior remain unclear. In this study we evaluated the effects of intra-CeA OT administration of different doses (0.1, 1 and 10ng/side), OT receptor antagonist (OTR-A) (1, 10 and 100ng/side) and OT plus OTR-A on social and emotional behavior using a social preference paradigm, open field test and elevated plus maze test in female monogamous mandarin voles (Microtus mandarinus). We then examined whether different doses of the GABAA receptor antagonist bicuculline (5, 10 and 100ng/side) affected the behavioral changes induced by intra-CeA microinjection of OT (1ng/side). We found that administration of OT to the CeA increased social preference, central area investigation times in the open field test, and visits, transitions and time spent in the open arms in the elevated plus maze test; all responses were dose-dependent. Administration of OT plus OTR-A to the CeA produced no effects. Administration of bicuculline in combination with OT to the CeA decreased social preference, central area investigation times in the open field test, and visits, transitions and time spent in the open arms of the elevated plus maze test. These data suggest that OT in the CeA facilitates sociality and reduces levels of anxiety by interacting with local GABAA receptors.

Publisher URL: www.sciencedirect.com/science

DOI: S0143417916302050

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.